Postdoctoral Associate
“Hydrogel Microsphere Technologies for Formulation of Crystalline Monoclonal Antibodies”
Applications are invited for a Postdoctoral Associate position in the Doyle Lab at MIT. The scholar will lead research efforts on an industrially sponsored project related to developing hydrogel microspheres for monoclonal antibody (mAb) formulations. The overarching goal of this project is to develop hydrogel-based formulations for high concentration antibody formulations with desired flow properties.1,2 The research will entail soft matter physics, micro- and milli-fluidic production of microgel particles, rheometry, microscopy, and in vitro releases studies. The postdoctoral associate will have frequent interactions with the pharmaceutical industrial collaborators.
Candidates should have experience in one or more of the following areas: Microfluidic design & fabrication, rheometry, soft materials design & hydrogels, microscopy, colloidal phenomena, and basic understanding of protein stability.
Required skills include: strong background in the quantitative sciences or chemical/bio/mechanical engineering, and strong communication skills. Familiarity with laboratory aseptic technique and familiarity/interest in building simple mechanical devices are helpful in this project.
Applicants must have a demonstrated record of impactful scientific contributions and a capacity to communicate effectively with experts from a range of disciplines (including clinicians). Interviews are underway now, with the position to be filled immediately.
To apply: please email (i) your cover letter & CV and (ii) the names and contact information for 3 references to Prof. Patrick Doyle (pdoyle [at] mit [dot] edu) “mAb Postdoc Application” in the subject line.
MIT is an equal opportunity employer, and we welcome diverse experiences, backgrounds and perspectives.
References:
1. Schieferstein, Narasimhan, Doyle, Advanced Therapeutics, 2000216, 2021.
2. Erfani, A., Schieferstein, J.M., Reichert, P., Narasimhan, C.N., Pastukovas, C., Parab, V., Simmons, D., Yang, X., Shanker, A., Hammond, P., and Doyle, P.S., Advanced Healthcare Materials, 2023.
Postdoctoral Scholar
“Microengineered Technologies to Spatially Profile microRNA in Tissue Sections”
Applications are invited for a Postdoctoral Scholar position in the Doyle Lab at MIT in the Chemical Engineering Department. The scholar will lead research efforts on a funded NIH R01 grant at MIT. The overarching goal of this project is to design, optimize, & apply a new microfabricated tool for spatially-resolved measurements of miRNA in tissue samples. The work will be performed at MIT and the project involves close collaboration with the group of Dr. Frank Slack (Department of Pathology, and Director of the Institute for RNA Medicine, BIDMC in Boston).
Candidates should have experience in one or more of the following areas: bioassays, microfluidic design & fabrication, soft materials design & hydrogels, quantitative imaging, and data processing. Required skills include: strong background in the quantitative sciences or chemical/bio/mechanical engineering, and strong communication skills.
Applicants must have a demonstrated record of impactful scientific contributions and a capacity to communicate effectively with experts from a range of disciplines (including clinicians). Interviews are underway now, with the position to be filled immediately (pending graduation/career plans of successful applicant).
To apply: please email (i) your cover letter & CV and (ii) the names and contact information for 3 references to Prof. Patrick Doyle (pdoyle [at] mit [dot] edu) “microRNA Postdoc Application” in the subject line.
MIT is an equal-opportunity employer.